解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:In our previous study, Citrobacter werkmanii BF-6 was isolated from an industrial spoilage sample and demonstrated an excellent ability to form biofilms, which could be affected by various environmental factors. However, the genome sequence of this organism has not been reported so far. RESULTS:We report th...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4157-9
更新日期:2017-10-10 00:00:00
abstract:BACKGROUND:The bulldog calf syndrome is a lethal form of the inherited congenital chondrodysplasias. Among the progeny of the polled Holstein bull Energy P cases of lethal chondrodysplasia were observed. Pedigrees of the cases and the frequency of 3/8 cases among the offspring of Energy P at our teaching and experiment...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4153-0
更新日期:2017-10-10 00:00:00
abstract:BACKGROUND:Colon cancer occurrence is increasing worldwide, making it the third most frequent cancer. Although many therapeutic options are available and quite efficient at the early stages, survival is strongly decreased when the disease has spread to other organs. The identification of molecular markers of colon canc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4139-y
更新日期:2017-09-30 00:00:00
abstract:BACKGROUND:We developed a novel software package, XCAVATOR, for the identification of genomic regions involved in copy number variants/alterations (CNVs/CNAs) from short and long reads whole-genome sequencing experiments. RESULTS:By using simulated and real datasets we showed that our tool, based on read count approac...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4137-0
更新日期:2017-09-21 00:00:00
abstract:BACKGROUND:Cell lines are an indispensable tool in biomedical research and often used as surrogates for tissues. Although there are recognized important cellular and transcriptomic differences between cell lines and tissues, a systematic overview of the differences between the regulatory processes of a cell line and th...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4111-x
更新日期:2017-09-12 00:00:00
abstract:BACKGROUND:Parkinson's disease (PD) is the second most prevalent neurodegenerative disorders in the world. Studying PD from systems biology perspective involving genes and their regulators might provide deeper insights into the complex molecular interactions associated with this disease. RESULT:We have studied gene co...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4098-3
更新日期:2017-09-12 00:00:00
abstract:BACKGROUND:The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway has been well-characterized as a crucial signal transduction cascade that regulates vital biological responses including development, immunity and oncogenesis. Additionally to its canonical pathway that uses the phosphorylat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4058-y
更新日期:2017-09-11 00:00:00
abstract:BACKGROUND:Due to the limited availability and high cost of fish oil in the face of increasing aquaculture production, there is a need to reduce usage of fish oil in aquafeeds without compromising farm fish health. Therefore, the present study was conducted to determine if different levels of vegetable and fish oils ca...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4099-2
更新日期:2017-09-08 00:00:00
abstract:BACKGROUND:Phomopsis longicolla T. W. Hobbs (syn. Diaporthe longicolla) is a seed-borne fungus causing Phomopsis seed decay in soybean. This disease is one of the most devastating diseases reducing soybean seed quality worldwide. To facilitate investigation of the genomic basis of pathogenicity and to understand the me...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4075-x
更新日期:2017-09-05 00:00:00
abstract:BACKGROUND:Distinguishing orthologous and paralogous relationships between genes across multiple species is essential for comparative genomic analyses. Various computational approaches have been developed to resolve these evolutionary relationships, but strong trade-offs between precision and recall of orthologue predi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4079-6
更新日期:2017-08-31 00:00:00
abstract:BACKGROUND:TEs pervade mammalian genomes. However, compared with mice, fewer studies have focused on the TE expression patterns in rat, particularly the comparisons across different organs, developmental stages and sexes. In addition, TEs can influence the expression of nearby genes. The temporal and spatial influences...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4078-7
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:High-throughput genotyping platforms play important roles in plant genomic studies. Cotton (Gossypium spp.) is the world's important natural textile fiber and oil crop. Upland cotton accounts for more than 90% of the world's cotton production, however, modern upland cotton cultivars have narrow genetic diver...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4062-2
更新日期:2017-08-23 00:00:00
abstract:BACKGROUND:The molecular mechanisms of transcriptional regulation are poorly understood in Plasmodium falciparum. In addition, most of the genes in Plasmodium falciparum are transcriptionally poised and only a handful of cis-regulatory elements are known to operate in transcriptional regulation. Here, we employed an ep...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4052-4
更新日期:2017-08-23 00:00:00
abstract:BACKGROUND:Equine influenza is a major health problem of equines worldwide. The polymerase genes of influenza virus have key roles in virus replication, transcription, transmission between hosts and pathogenesis. Hence, the comprehensive genetic and codon usage bias of polymerase genes of equine influenza virus (EIV) w...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4063-1
更新日期:2017-08-23 00:00:00
abstract:BACKGROUND:Sub-optimal developmental diets often have adverse effects on long-term fitness and health. One hypothesis is that such effects are caused by mismatches between the developmental and adult environment, and may be mediated by persistent changes in gene expression. However, there are few experimental tests of ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3968-z
更新日期:2017-08-22 00:00:00
abstract:BACKGROUND:Polyploidy is an important phenomenon in plants because of its roles in agricultural and forestry production as well as in plant tolerance to environmental stresses. Tetraploid black locust (Robinia pseudoacacia L.) is a polyploid plant and a pioneer tree species due to its wide ranging adaptability to adver...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4038-2
更新日期:2017-08-22 00:00:00
abstract:BACKGROUND:The importance of poultry as a global source of protein underpins the chicken genome and associated SNP data as key tools in selecting and breeding healthy robust birds with improved disease resistance. SNPs affecting host peptides involved in the innate defences tend to be rare, but three non-synonymous SNP...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4034-6
更新日期:2017-08-18 00:00:00
abstract:BACKGROUND:Fungal pathogens of plants produce diverse repertoires of secondary metabolites, which have functions ranging from iron acquisition, defense against immune perturbation, to toxic assaults on the host. The wheat pathogen Zymoseptoria tritici causes Septoria tritici blotch, a foliar disease which is a signific...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3969-y
更新日期:2017-08-17 00:00:00
abstract:BACKGROUND:Decades of intensive genetic selection in the domestic chicken (Gallus gallus domesticus) have enabled the remarkable rapid growth of today's broiler (meat-type) chickens. However, this enhanced growth rate was accompanied by several unfavorable traits (i.e., increased visceral fatness, leg weakness, and dis...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4035-5
更新日期:2017-08-16 00:00:00
abstract:BACKGROUND:In biomedical research, gene expression profiling studies have been extensively conducted. The analysis of gene expression data has led to a deeper understanding of human genetics as well as practically useful models. Clustering analysis has been a critical component of gene expression data analysis and can ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3990-1
更新日期:2017-08-16 00:00:00
abstract:BACKGROUND:Dimethylsulfoniopropionate (DMSP) is a small sulphur compound which is produced in prodigious amounts in the oceans and plays a pivotal role in the marine sulfur cycle. Until recently, DMSP was believed to be synthesized exclusively by photosynthetic organisms; however we now know that corals and specific ba...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3959-0
更新日期:2017-08-14 00:00:00
abstract:BACKGROUND:A better understanding of the genetic architecture underlying complex traits (e.g., the distribution of causal variants and their effects) may aid in the genomic prediction. Here, we hypothesized that the genomic variants of complex traits might be enriched in a subset of genomic regions defined by genes gro...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4004-z
更新日期:2017-08-10 00:00:00
abstract:BACKGROUND:Though Illumina has largely dominated the RNA-Seq field, the simultaneous availability of Ion Torrent has left scientists wondering which platform is most effective for differential gene expression (DGE) analysis. Previous investigations of this question have typically used reference samples derived from cel...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4011-0
更新日期:2017-08-10 00:00:00
abstract:BACKGROUND:Mytilisepta virgata is a marine mussel commonly found along the coasts of Japan. Although this species has been the subject of occasional studies concerning its ecological role, growth and reproduction, it has been so far almost completely neglected from a genetic and molecular point of view. In the present ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4012-z
更新日期:2017-08-08 00:00:00
abstract:BACKGROUND:Enterohemorrhagic Escherichia coli (EHEC) are zoonotic agents associated with outbreaks worldwide. Growth of EHEC strains in ground beef could be inhibited by background microbiota that is present initially at levels greater than that of the pathogen E. coli. However, how the microbiota outcompetes the patho...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3957-2
更新日期:2017-08-03 00:00:00
abstract:BACKGROUND:Gibel carp is an important aquaculture species in China, and a herpesvirus, called as Carassius auratus herpesvirus (CaHV), has hampered the aquaculture development. Diverse gynogenetic clones of gibel carp have been identified or created, and some of them have been used as aquaculture varieties, but their r...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3945-6
更新日期:2017-07-24 00:00:00
abstract:BACKGROUND:The Iberian lynx (Lynx pardinus) has been acknowledged as the most endangered felid species in the world. An intense contraction and fragmentation during the twentieth century left less than 100 individuals split in two isolated and genetically eroded populations by 2002. Genetic monitoring and management so...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3946-5
更新日期:2017-07-21 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) regulate adipose tissue metabolism, however, their function on testosterone deficiency related obesity in humans is less understood. For this research, intact and castrated male pigs are the best model animal because of their similar proportional organ sizes, cardiovascular sys...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3907-z
更新日期:2017-07-19 00:00:00
abstract:BACKGROUND:Soybean seed weight is not only a yield component, but also a critical trait for various soybean food products such as sprouts, edamame, soy nuts, natto and miso. Linkage analysis and genome-wide association study (GWAS) are two complementary and powerful tools to connect phenotypic differences to the underl...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3922-0
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:Aeromonas salmonicida subsp. salmonicida is a ubiquitous psychrophilic waterborne bacterium and a fish pathogen. The numerous mobile elements, especially insertion sequences (IS), in its genome promote rearrangements that impact its phenotype. One of the main virulence factors of this bacterium, its type thr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3921-1
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:Genomic studies such as genome-wide association and genomic selection require genome-wide genotype data. All existing technologies used to create these data result in missing genotypes, which are often then inferred using genotype imputation software. However, existing imputation methods most often make use ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3873-5
更新日期:2017-07-10 00:00:00
abstract:BACKGROUND:Technological advances have enabled transcriptome characterization of cell types at the single-cell level providing new biological insights. New methods that enable simple yet high-throughput single-cell expression profiling are highly desirable. RESULTS:Here we report a novel nanowell-based single-cell RNA...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3893-1
更新日期:2017-07-07 00:00:00
abstract:BACKGROUND:Pre-harvest sprouting frequently occurs in Triticum aestivum (wheat) and Hordeum vulgare (barley) at the end of the maturity period due to high rainfall, particularly in Asian monsoon areas. Seed dormancy is a major mechanism preventing pre-harvest sprouting in these crops. RESULTS:We identified orthologous...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3880-6
更新日期:2017-06-29 00:00:00
abstract:BACKGROUND:Cornu aspersum is a quite intriguing species from the point of view of ecology and evolution and its potential use in medical and environmental applications. It is a species of economic importance since it is farmed and used for culinary purposes. However, the genomic tools that would allow a thorough insigh...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3885-1
更新日期:2017-06-28 00:00:00
abstract::We describe an emerging initiative - the 'Functional Annotation of All Salmonid Genomes' (FAASG), which will leverage the extensive trait diversity that has evolved since a whole genome duplication event in the salmonid ancestor, to develop an integrative understanding of the functional genomic basis of phenotypic var...
journal_title:BMC genomics
pub_type: 社论
doi:10.1186/s12864-017-3862-8
更新日期:2017-06-27 00:00:00
abstract:BACKGROUND:Intensive selection has resulted in increased growth rates and muscularity in broiler chickens, in addition to adverse effects, including delayed organ development, sudden death syndrome, and altered metabolic rates. The biological mechanisms underlying selection responses remain largely unknown. Non-artific...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3845-9
更新日期:2017-06-20 00:00:00
abstract:BACKGROUND:Finger millet (Eleusine coracana (L.) Gaertn.) is an important staple food crop widely grown in Africa and South Asia. Among the millets, finger millet has high amount of calcium, methionine, tryptophan, fiber, and sulphur containing amino acids. In addition, it has C4 photosynthetic carbon assimilation mech...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3850-z
更新日期:2017-06-15 00:00:00
abstract:BACKGROUND:Pectins are plant cell wall polysaccharides that can be acetylated on C2 and/or C3 of galacturonic acid residues. The degree of acetylation of pectin can be modulated by pectin acetylesterase (EC 3.1.1.6, PAE). The function and structure of plant PAEs remain poorly understood and the role of the fine-tuning ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3833-0
更新日期:2017-06-08 00:00:00
abstract:BACKGROUND:RNA sequencing (RNA-seq) and microarrays are two transcriptomics techniques aimed at the quantification of transcribed genes and their isoforms. Here we compare the latest Affymetrix HTA 2.0 microarray with Illumina 2000 RNA-seq for the analysis of patient samples - normal lung epithelium tissue and squamous...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3819-y
更新日期:2017-06-06 00:00:00
abstract:BACKGROUND:Mycoviruses are viruses that naturally infect and replicate in fungi. Aspergillus fumigatus, an opportunistic pathogen causing fungal lung diseases in humans and animals, was recently shown to harbour several different types of mycoviruses. A well-characterised defence against virus infection is RNA silencin...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3773-8
更新日期:2017-05-30 00:00:00